Welcome to Fox Pharma’s A-Z Guide To Toxins! In this blog, we’ve compiled all the essential information that practitioners need to know about the wide range of toxins (anti-wrinkle injections) that we stock at Fox Pharma. From Azzalure to our newest addition, Letybo, we’ve got you covered.
Anti-wrinkle injections have become one of the most popular treatments for those looking to maintain a youthful appearance. With this increase in demand, it’s more important than ever for practitioners to have a comprehensive understanding of the toxins they’re using – especially when it comes to deciding which toxin is most suited to their clinic and their patient roster.
At Fox Pharma, we pride ourselves on our commitment to providing high-quality products and reliable information to our customers. This guide is just one example of that commitment, as we aim to educate practitioners on the toxins they’re using and the best practices for administering them. So, whether you’re a seasoned practitioner or just starting out, we hope you find this guide informative and helpful in your practice
| Alluzience | Data supporting the positive decision demonstrated that patients treated with Alluzience for wrinkles had a rapid onset of effect starting from 2-3 days, with improvements lasting up to six months – double the time of other popular anti-wrinkle injections which are usually ready for a re-treatment every 12-16 weeks. Study: Ascher B, Rzany B, Kestemont P, et al. Liquid Formulation of AbobotulinumtoxinA: A 6-Month, Phase 3, Double-Blind, Randomized, Placebo Controlled Study of a Single Treatment, Ready-to Use Toxin for Moderate-to-Severe Glabellar Lines. Aesthet Surg J. 2020;40(1):93–104. The first ready-to-use BoNT-A liquid neuromodulator formulation to be introduced in Europe. End results like leading competitor brands. | The recommended dose is 0.25 ml of solution (50 Speywood units) divided into 5 injection sites, 0.05 ml of solution (10 Speywood units) administered intramuscularly into each of the 5 sites: 2 injections into each corrugator muscle and one into the procerus muscle, near the nasofrontal angle. | Hypersensitivity to the active substance or to any of the excipients. Presence of infection at the proposed injection sites. Presence of myasthenia gravis, Eaton Lambert Syndrome, or amyotrophic lateral sclerosis | 125 units in 0.625ml of solution ready to use (no dilution required) |
| Azzalure | Specifically developed for use in medical aesthetic treatments Has a particularly quick mode of action between 2-3 days Results have been shown to last longer than 4months | Glabellar Lines: The recommended dose is 50 Speywood units of Azzalure to be divided into 5 injection sites, 10 Speywood units are to be administered intramuscularly, at right angles to the skin, into each of the 5 sites: 2 injections into each corrugator muscle and one into the procerus muscle near the nasofrontal angle. Lateral Canthal Lines: The recommended dose per side is 30 Speywood units of Azzalure, to be divided into 3 injection sites; 10 Speywood units are to be administered intramuscularly into each injection point. Injection should be lateral (20 – 30° angle) to the skin and very superficial. All injection points should be at the external part of the orbicularis oculi muscle and sufficiently far from the orbital rim (approximately 1-2 cm) | Hypersensitivity to the active substance or to any of the excipients. Presence of infection at the proposed injection sites. Presence of myasthenia gravis, Eaton Lambert Syndrome, or amyotrophic lateral sclerosis | If you dilute a vial of Azzalure 125 units with 0.63ml of Sodium Chloride 0.9%, you will achieve a concentration of 10 units per 0.05ml. If you dilute a vial of Azzalure 125 units with 1.25ml of Sodium Chloride 0.9% you will achieve a concentration of 10 units per 0.1ml |
| Bocouture | Bocouture is the first and only purified botulinum toxin formulation free of complex proteins, with a molecular weight of only 150kD. This reduces the likelihood of neutralising antibodies forming, even in high doses. Bocouture is more stable at room temperature and doesn’t need to be stored in the fridge. Performs equally as well as other market-leading anti-wrinkle injections both in terms of speed of effect, and, in terms of duration of effect. | Glabellar Lines: After reconstitution, a dose of 4 units is injected into each of the 5 injection sites: two injections in each corrugator muscle and one injection in the procerus muscle, which corresponds to a standard dose of 20 units. The dose may be increased by the physician to up to 30 units if required by the individual needs of the patients, with at least ‘3-months’ interval between treatments. Crow’s Feet Lines: After reconstitution, 4 units are injected bilaterally into each of the 3 injection sites. One injection is placed approximately 1 cm lateral from the bony orbital rim. The other two injections each should be placed approximately 1 cm above and below the area of the first injection. The total recommended standard dose per treatment is 12 units per side (overall total dose: 24 units). | Hypersensitivity to the active substance or to any of the excipients. Generalised disorders of muscle activity (e.g. myasthenia gravis, Lambert- Eaton syndrome). Infection or inflammation at the proposed injection site. | If you dilute a vial of Bocouture 50 units with 1.25ml of Sodium Chloride 0.9%, you will achieve a concentration of 4 units per 0.1ml. If you dilute a vial of Bocouture 100 units with 2.5ml of Sodium Chloride 0.9% you will achieve a concentration of 4 units per 0.1ml |
| Botox | The best-known brand of botulinum toxin Backed by 16 years of published studies and uses a unique manufacturing process Botox’s potency is measures in units that are not interchangeable to another | Glabellar Lines: A volume of 0.1 ml (4 Units) is administered in each of the 5 injection sites: injections in each corrugator muscle and 1 injection in the procerus muscle for a total dose of 20 Units. To reduce the risk of eyelid ptosis, the maximum dose of 4 Units for each injection site as well as the number of injection sites should not be exceeded. Crow’s Feet Lines: A volume of 0.1 ml (4 Units) is administered in each of the 3 injection sites per side (total of 6 injection sites) in the lateral orbicularis oculi muscle, for a total dose of 24 Units in a total volume of 0.6 ml (12 Units per side). For simultaneous treatment with glabellar lines seen at maximum frown, the dose is 24 Units for crow’s feet lines seen at maximum smile and 20 Units for glabellar lines for a total dose of 44 Units in a total volume of 1.1 ml. In order to reduce the risk of eyelid ptosis, the maximum dose of 4 Units for each injection site as well as the number of injection sites should not be exceeded | Known hypersensitivity to botulinum toxin type A or to any of the excipients Presence of infection at the proposed injection site(s) | If you dilute a vial of Botox 50 units with 1.25ml of Sodium Chloride 0.9%, you will achieve a concentration of 4 units per 0.1ml. If you dilute a vial of Botox 100 units with 1.25ml of Sodium Chloride 0.9%, you will achieve a concentration of 4 units per 0.1ml. If you dilute a vial of Botox 200 units with 1.25ml of Sodium Chloride 0.9%, you will achieve a concentration of 4 units per 0.1ml. |
| Letybo | Letybo received a 94% response rate four weeks after injection, in a trial of >1000 participants conducted by Chroma-Pharma In each study, letibotulinumtoxinA was superior to a placebo in reducing glabellar (frown) line severity at week 4. Results similar to leading competitor brands. Lower-cost alternative to leading brand. Suitable for patients under 75 years old | The recommended dose of Letybo is a total of 20 units, divided into 5 injections of 4 units each for the treatment of the glabellar lines. – refer to muscle instead Letybo is delivered as a white powder, to be reconstituted as a solution for injection. A single vial contains 50 units of botulinum toxin type A which is produced by Clostridium botulinum. | Hypersensitivity to the active substance or to any of the excipients Presence of acute infection or inflammation at the proposed injection sites Generalised disorders of muscle activity such asmyasthenia gravis, Lambert-Eaton syndrome, amyotrophic lateral sclerosis | If you dilute a vial of Letybo 50 with units with 1.25ml of Sodium Chloride 0.9% you will achieve a concentration of 4 units per 0.1ml |
| Dysport | Dysport is much more diluted and spreads quicker in comparison to other toxins. Dysport produces results in just a short amount of time – quicker than other anti-wrinkle injectables | Not licensed for use on the face, only for hyperhidrosis. | Hypersensitivity to the active substance or to any of the excipients. | If you dilute a vial of Dysport 500 with units with 1ml of Sodium Chloride 0.9% you will achieve a concentration of 500 units per 1ml Dilution with 2.5ml of Sodium Chloride 0.9% will achieve a concentration of 200 units per ml. Dilution with 5ml of Sodium Chloride 0.9% will achieve a concentration of 100 units per ml |
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